Mild Behavior Impairment (MBI) can be an early manifestation of the dementia process, associating with biomarkers for Alzheimer’s disease and other neurodegenerative conditions, in advance of cognitive decline in some.
Dr. Zahinoor Ismail at the University of Calgary, together with ISTAART colleagues, created the Mild Behavioral Impairment Checklist (MBI-C). The MBI-C can help clinicians note changes in longstanding patterns of behavior or personality that can be symptoms of incident cognitive decline and dementia. The MBI-C can identify disease severity, with MBI-C scores increasing from subjective cognitive decline to mild cognitive impairment, to dementia.
AREAS OF APPLICATION
- Clinical trials
- Research studies
- Clinical diagnosis, treatment, and management
- Case ascertainment instrument for Mild Behavioral Impairment, based on the ISTAART-AA diagnostic criteria.
- Early identification of patients at risk of developing Alzheimer’s and other dementias .
- Designed to be used by family members and caregivers of older adults making it easy to comprehend and apply.
PUBLICATIONS AND RESOURCES
- Journal publications:
- Ismail Z et al. (2017). The Mild Behavioral Impairment Checklist (MBI-C): A rating scale for neuropsychiatric symptoms in pre-dementia populations. Journal of Alzheimer’s Disease 56(3): 929-938.
- Kassam F et al. (2022). Cognitive profile of people with mild behavioral impairment in Brain Health Registry participants. International Psychogeriatrics 2022: 1-10.
- Lussier FZ et al. (2020). Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals. Alzheimer’s & Dementia 16(1): 192-199.
- Ismail Z et al. (2016). Neuropsychiatric symptoms as early manifestations of emergent dementia: Provisional diagnostic criteria for mild behavioral impairment. Alzheimer’s & Dementia 12 (2): 195-202.
- Mallo SC et al. (2018). Assessing mild behavioral impairment with the mild behavioral impairment checklist in people with subjective cognitive decline. International Psychogeriatrics 18: 1-9.
- Mallo SC et al. (2018). Assessing mild behavioral impairment with the mild behavioral impairment-checklist in people with mild cognitive impairment. Journal of Alzheimer’s Disease. Epub.
- Learn more: MBItest.org
- Lead researcher profile: Zahinoor Ismail