Biosensor for the Detection of Antibodies and Small Molecules

A novel platform technology for point-of-care non-invasive tests.
Tech ID #: 872.5
IP status: US composition of matter patent granted January 2022.
Prototype available: proof of principle has been validated on various clinical samples.
Inexpensive and easy to use: no sample purification and processing needed.
Fast: test results available from 10 minutes to one hour, depending on the target.


Researchers at the University of Calgary have created a point-of-care (POC) biosensor platform for any small molecule or biological samples. This biosensor relies on cognate enzyme complementation and produces glucose as a final product. The resultant glucose can be easily measured using common or custom-build glucometers. This new method provides a way to detect a wide range of analytes in various biological samples, including blood and colostrum, with a high degree of specificity and sensitivity.



Verified in clinical samples:

  • Small molecule detection – bovine serum calcium test for hypocalcaemia diagnosis1.
  • Antibody detection – sera antibody test against bovine leukemia virus (BLV)2,3.
  • Immunoglobulin detection:
    • Serum IgG concentration test in various animal species4.
    • Colostrum IgG concentration test5.
  • Genetic targets, after amplicons by PCR or isothermal amplification (LAMP)6.
  • Protein aggregation detection3.



  • High sensitivity and specificity demonstrated on various clinical samples.
  • Portable, inexpensive, and simple to use – direct use on biological samples, no purification or processing needed.
  • Fast – test results can be available within 10 minutes.
  • The inventor has access to large animal resources for clinical trials.




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