University of Calgary researcher Dr. Julie Deans has produced a monoclonal antibody (mouse IgG2A) against human MS4A8B. MS4A8B is a member of the MS4A family expressed in epithelial cells found in various tissues, particularly in the lung and trachea. Importantly, MS4A8B is overexpressed in both prostate cancer and small cell carcinoma in the lung, suggesting a potential role as a biomarker and/or therapeutic target in these diseases.
A quality antibody against MS4A8B can be valuable for both pre-clinical and clinical research applications. This anti-MS4A8B antibody detects an extracellular epitope, has no observed cross-reactivity and has been used successfully for flow cytometry (FC), immunoblotting (IB), and immunoprecipitation (IP).
AREAS OF APPLICATION
- Prostate cancer
- Small cell carcinoma (lung)
- Extremely specific
- Multiple applications (IB, IP, FC)
- Binds to extracellular domain
- No need to permeabilize cells
STAGE OF DEVELOPMENT:
- Hybridoma licensed to Kerafast EUC001
- Researcher profile: Dr. Julie P. Deans
- Publication: Immunol Cell Biol. 2017 Apr 11. doi: 10.1038/icb.2017.18.